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PriMed Spontaneously Non-human Primate Model of Type 2 Diabetes

PriMed Shines provides the worlds largest collection of well-characterized spontaneous diabetic rhesus monkeys. NHP models of Type 2 diabetes (T2DM) display all of the characteristics of diabetic patients at different stages of the progressive disease, including obesity, and complications such as nephropathy and retinopathy. Our well-characterized models have been validated for metabolic defects including glucose intolerance, impaired insulin response, insulin resistance, impaired pancreatic insulin secretion function, reduced glucose disposition, etc.

PriMed Spontaneous T2DM NHP Capability

Breeding center: n=~3000 rhesus macaques.
Colony of n=~300 well-characterized spontaneously diabetic rhesus monkeys.
Historical clinical /metabolic data (7yrs.) by semiannual metabolic screenings.
Plasma and tissue sets cover normal to prediabetic, diabetic, and insulin dependen tdiabetic NHPs.
T2DM NHP management collaborated with Dr.Barbara C.Hansen

In vivo pharmacology capabilities include the evaluation of

 Compound’s pharmacological properties (dose-response, efficacy, and PK)

 Blood chemistry (lipid profile etc.)

 Body weight/body composition

 Food and liquid consumption

 Fasting glucose and insulin index Glucose disposal rate (ivGTT, OGTT)

 Islet function (graded glucose infusion, GGI)

 Glucose disposition and insulin sensitivity (glucose and insulin clamps)

 Renal function (urine volume, protein, glucose, creatinine excretion, GFR)

 Continuous glucose monitoring by telemetry

 Safety pharmacology: potential side effects

 Biopsy/autopsy, histopathology

 Heart or liver function (noninvasive sonography)

      Type 2 Diabetes in Human and NHPs: the same diseases!

PriMed Posters and Publications

ADA 77th Scientific Sessions, San Diego

27-LB: Diabetic Kidney Disease (DKD) in Nonhuman Primates (NHP’s) Is Comparable to Humans for Glomerular Filtration Rate (GFR), Histology, and High-Risk Factors

488-P: A Plant-Derived Drug Improves the Cardiac Function of Monkeys with Heart Failure and Type 2 Diabetes

2427-PUB: Determination and Evaluation of Hypertension in a Nonhuman Primate Model of Type 2 Diabetes

1993-P: Adaptation of Slow- and Fast-twitch Skeletal Muscles to Type 2 Diabetes Mellitus (T2DM) in Diabetic Rhesus Monkeys: an Initial Experience with Non-contrast MRI Microcirculation Mapping Techniques.

485-P: Application of CMR T1ρ Mapping and T1 Mapping in Diagnosis of Diffuse Myocardial Fibrosis in Type 2 Diabetes Mellitus Rhesus Monkeys with Myocardial Diastolic Dysfunction.

2017 Keystone Symposium on Bile Acid Receptors as Signal Integrators in Liver and Metabolism, Monterey 

Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Nonhuman Primates (NHP’s) is Comparable to Humans for Metabolic Features, Histology and Imaging

ADA 76th Scientific Sessions, New Orleans

217-OR: Diffuse Myocardial Fibrosis Quantified by T1 Mapping at 3 T Increases in Early Diabetic Cardiomyopathy: A Preclinical Validation Study in Nonhuman Primates

ICO 2016, Vancouver

Diagnosis Of Naturally-occurring Non-alcoholic Steatohepatitis (NASH) In Obese Rhesus Monkeys Using Histopathology Criteria

Quantification Of Hepatic Fat In Naturally-occurring Nonalcoholic Fatty Liver Disease (NAFLD) In Obese Rhesus Monkeys Using Dual-energy CT (DECT)

ADA 75th Scientific Sessions, Boston

2891-PO: The Characteristics of Blood Pressure of Type 2 Diabetic Monkeys

544-P: Screening of Diabetic Nephropathy in Spontaneous Type 2 Diabetic Rhesus Monkeys

2122-P: Effects of a Long-Acting Formulation of Exenatide on Glucose and Weight Control in Type 2 Diabetic Rhesus Monkeys

1840-P: Blood-Brain Barrier Permeability Increased in Rhesus Monkeys with Spontaneous T2DM: A Non-Invasive MRI Study

2393-PO: The Pathophysiology and Diagnosis for Spontaneous Type 2 Diabetes Mellitus Associated Diastolic Dysfunction in Rhesus Monkeys

More information about posters and publications                                                     

Contact Us Right Now

Email : bd@scprimed.com

Tel : +86-28-85921823

Fax : +86-28-62491302

Zip code : 610041

Address : Floor 5, Incubator B4,Tianfu Life & Science Park, No. 88 Southern Keyuan Road,High-tech Zone, Chengdu, Sichuan, China, 610041

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