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PriMed Non-human Primate Model of Cardiac Diastolic Dysfunction







PriMed Heart Failure NHP Capability: 

 Set up 230 dysmetabolic rhesus ECHO database


 With longitudinal(>5 years) medical records, including echo, clinical pathology, body weight, food intake, vet treatment and dosing record.


 ~60 dyslipidemia rhesus with systolic dysfunction.


 ~100 pre-diabetic/diabetic rhesus with diastolic dysfunction were identified.


 

Imaging Capability: 

 Extensive Echo and MRI experienceswith monkey cardiac testing


 Equipped with advanced Echo, MRI and CVI software and EchoPAC Software onsite.


 Cardiac function(Echo, MRI tagging).


 Myocardial fibrosis (T1ρ, T1 mapping).


 Myocardial microcirculation (MRI perfusion, oxygen extraction fraction.


 30-year imaging expert as CSO, an echo team with 8 employees(>2 year experience).



Benchmark Study: 

 Entresto and Valsartan have been validated with our HF NHP models


 Echo and MRI were used for outcomes measurement


 PK/PD and toxicity profiling




Case Example: 

 


PriMed Posters and Publications


ADA 77th Scientific Sessions, San Diego

488-P: A Plant-Derived Drug Improves the Cardiac Function of Monkeys with Heart Failure and Type 2 Diabetes

1993-P: Adaptation of Slow- and Fast-twitch Skeletal Muscles to Type 2 Diabetes Mellitus (T2DM) in Diabetic Rhesus Monkeys: an Initial Experience with Non-contrast MRI Microcirculation Mapping Techniques.

485-P: Application of CMR T1ρ Mapping and T1 Mapping in Diagnosis of Diffuse Myocardial Fibrosis in Type 2 Diabetes Mellitus Rhesus Monkeys with Myocardial Diastolic Dysfunction.



ADA 76th Scientific Sessions, New Orleans

217-OR: Diffuse Myocardial Fibrosis Quantified by T1 Mapping at 3 T Increases in Early Diabetic Cardiomyopathy: A Preclinical Validation Study in Nonhuman Primates


ADA 75th Scientific Sessions, Boston

1840-P: Blood-Brain Barrier Permeability Increased in Rhesus Monkeys with Spontaneous T2DM: A Non-Invasive MRI Study

2393-PO: The Pathophysiology and Diagnosis for Spontaneous Type 2 Diabetes Mellitus Associated Diastolic Dysfunction in Rhesus Monkeys


More information about posters and publications                                                     


Contact Us Right Now


              

Email : bd@scprimed.com

Tel : +86-28-85921823

Fax : +86-28-62491302

Zip code : 610041

Address : Floor 5, Incubator B4,Tianfu Life & Science Park, No. 88 Southern Keyuan Road,High-tech Zone, Chengdu, Sichuan, China, 610041


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