PriMed Non-human Primate Model of Cardiac Diastolic Dysfunction
PriMed Heart Failure NHP Capability:
Set up 230 dysmetabolic rhesus ECHO database
With longitudinal(>5 years) medical records, including echo, clinical pathology, body weight, food intake, vet treatment and dosing record.
~60 dyslipidemia rhesus with systolic dysfunction.
~100 pre-diabetic/diabetic rhesus with diastolic dysfunction were identified.
Extensive Echo and MRI experienceswith monkey cardiac testing
Equipped with advanced Echo, MRI and CVI software and EchoPAC Software onsite.
Cardiac function(Echo, MRI tagging).
Myocardial fibrosis (T1ρ, T1 mapping).
Myocardial microcirculation (MRI perfusion, oxygen extraction fraction.
30-year imaging expert as CSO, an echo team with 8 employees(>2 year experience).
Entresto and Valsartan have been validated with our HF NHP models
Echo and MRI were used for outcomes measurement
PK/PD and toxicity profiling
PriMed Posters and Publications
ADA 77th Scientific Sessions, San Diego
488-P: A Plant-Derived Drug Improves the Cardiac Function of Monkeys with Heart Failure and Type 2 Diabetes
1993-P: Adaptation of Slow- and Fast-twitch Skeletal Muscles to Type 2 Diabetes Mellitus (T2DM) in Diabetic Rhesus Monkeys: an Initial Experience with Non-contrast MRI Microcirculation Mapping Techniques.
485-P: Application of CMR T1ρ Mapping and T1 Mapping in Diagnosis of Diffuse Myocardial Fibrosis in Type 2 Diabetes Mellitus Rhesus Monkeys with Myocardial Diastolic Dysfunction.
ADA 76th Scientific Sessions, New Orleans
217-OR: Diffuse Myocardial Fibrosis Quantified by T1 Mapping at 3 T Increases in Early Diabetic Cardiomyopathy: A Preclinical Validation Study in Nonhuman Primates
ADA 75th Scientific Sessions, Boston
1840-P: Blood-Brain Barrier Permeability Increased in Rhesus Monkeys with Spontaneous T2DM: A Non-Invasive MRI Study
2393-PO: The Pathophysiology and Diagnosis for Spontaneous Type 2 Diabetes Mellitus Associated Diastolic Dysfunction in Rhesus Monkeys
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