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PriMed Non-human Primate Model of Age-related Macular Degeneration

Age-related macular degeneration (AMD) is the leading cause of blindness among aged people in developed countries. The formation of choroidal neovascularization (CNV) is responsible for severe central vision loss associated with neovascular AMD. PriMed Shines has both spontaneous dry AMD and laser-induced CNV NHP models.


Spontaneous Age-related Macular Degeneration

 Set up 24 eyes of 12 monkeys (17-22 years) OCT and FP database.

 OCT and FP examination and analysis collaborated with Dr. Timothy Kern's team of Case Western Reserve University.

Imaging Capability 

 Extensive OCT and FP experience.

  Heidelberg Spectralis plus OCT.
  Kowa Fundus Camera.
  Fluorescence Angiography.
  Roland Electroretinogram.
  Imaging team with 10 employees (>2-yrs)

 OCT focusing on retinal thickness, cyst and fluid, drusen.

 Retinal thickness analysis: thickness Map, point counting.

 FP focusing on retinal exudate, hemorrhage, morphological changes of vessels, optic nerve by SIVA software.

Choroidal Neovascularization

 Laser induced CNV

  Validated with Lucentis and Avastin
  OCT, Fluorescence Angiography and histopathological analysis were used for outcomes measurement











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