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Translate preclinical findings sooner to help make smarter clinical decisions

Our unique non-human primate models of CVMD, ophthalmic diseases, renal disease, liver disease and inflammation can better predict human response to therapeutic candidates and provide insight and understanding about a drug's efficacy, pharmacological profile, reducing failure in the clinic, and supporting the selection of the right patients for the right therapy.

The primary reason for late stage drug failure in clinical trials is the inability to document improvement in outcomes. Therefore, PriMeds NHP disease models can be used at various stages of preclinical research to help you get answers on key efficacy readouts earlier and gain critical information for your go / no-godecision.







Cardiovascular and Metabolic Disease (CVMD)

PriMed has the worlds largest collection of well-characterized naturally dysmetabolic rhesus monkeys (n=700), which mirrors every aspect of the human disease including disease progression, obesity, dyslipidemia and complications such as nephropathy, retinopathy and heart failure. Using animal models with such a close resemblance to human disease should result in the most reliable preclinical data.


Spontaneously Heart Failure Non-human Primate

PriMed assessed cardiac function by GE vivid S5 color doppler ultrasound and 3T MRI in our spontaneously dysmetabolic NHPs. Criteria of NHP heart failure including heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) has been set up in our colony. We have about 200 rhesus monkeys with systolic dysfunction and diastolic dysfunction and all these monkeys have long term (> 5 years) medical records. Our extensive Echo and MRI experience with monkey heart testing can help our clients gain valuable insight and understanding into their candidates.


Spontaneously Diabetic Non-human Primate

Non-human primate (NHP) models of diabetes are the most clinically translatable animal model in T2DM. NHP models that spontaneously develop diabetes show all of the characteristics of T2DM patients at different stages of the progressive disease, and also develop late stage complications such as diabetic nephropathy, retinopathy et al.


NAFLD/NASH

The non-human primate NAFLD/NASH model, permitting both repeated liver biopsies and imaging studies, provides new opportunities to understand the pathogenesis as well as to examine in detail both the progression of the disease and its response to new therapeutic agents. PriMed has a large collection of rhesus NAFLD/NASH NHP models, which mirror every aspect of the human disease including steatosis, inflammation and ballooning. Diagnostic criteria according to human has been established by dual energy CT and histopathology of ultrasound-guided liver biopsy. PriMed has demonstrated for the first time that, like human disease, obese, dysmetabolic, and diabetic NHPs also develop NAFLD/NASH. 







Email : bd@scprimed.com

Tel : +86-28-85921823

Fax : +86-28-62491302

Zip code : 610041

Address : Floor 5, Incubator B4,Tianfu Life & Science Park, No. 88 Southern Keyuan Road,High-tech Zone, Chengdu, Sichuan, China, 610041


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