PriMed Non-human Primate Model of Nonalcoholic Fatty Liver Disease (NAFLD/NASH)
Spontaneously obese and dysmetabolic NHPs develop hepatic pathology with characteristics of NAFLD/NASH. The NHP model, permitting both repeated liver biopsies and multiple imaging studies, provides new opportunities to understand the pathogenesis as well as to examine in detail (with sequential repeated liver biopsies and longitudinal metabolic biomarkers) both the progression of the disease and its response to new therapeutic agents.
Using our unique spontaneously obese and dysmetabolic NHPs we developed ultrasonography and Dual Energy CT methods for noninvasive measurement of hepatic steatosis and other pathologic changes in correlation with multiple metabolic disorders and liver fibrosis biomarkers.
PriMed Shines NAFLD/NASH NHP Capability
Breeding center: n=~3000 rhesus macaques (macaca mulatta)
Set up 70 NAFLD/NASH rhesus macaques database.
Advanced imaging technology for all disease models
Extensive Siemens SOMATOM Definition Flash Dual Energy CT and GE Echo experience for monkey liver fat content quantification.
Targets of GLP-1 and FXR have been validated with our models.
PriMed Posters and Publications
2017 Keystone Symposium on Bile Acid Receptors as Signal Integrators in Liver and Metabolism, Monterey
Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Nonhuman Primates (NHP’s) is Comparable to Humans for Metabolic Features, Histology and Imaging
Experimental Biology 2017
Diagnosis of Naturally-occurring Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Rhesus Monkeys using dual-energy CT (DECT) and Histopathology Criteria
APASL 2017, Shanghai
1652: Pathological Study of Non-alcoholic Steatohepatitis (NASH) in Rhesus Monkeys
1663: A Novel FXR Agonist (HT03) for the Treatment of Nonalcoholic Steatohepatitis (NASH) in Rhesus Monkeys with NASH: Evaluation by Dual-energy CT (DECT) and Histopathology
ICO 2016, Vancouver
Diagnosis Of Naturally-occurring Non-alcoholic Steatohepatitis (NASH) In Obese Rhesus Monkeys Using Histopathology Criteria
Quantification Of Hepatic Fat In Naturally-occurring Nonalcoholic Fatty Liver Disease (NAFLD) In Obese Rhesus Monkeys Using Dual-energy CT (DECT)
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