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PriMed Non-human Primate Model of Diabetic Kidney Disease

Diabetes is the largest cause of kidney disease in the world. In fact, approximately 10% to 20% of mortality in diabetic patients is resulted from the kidney (renal) failure.


PriMed Shines provides a large collection of well-characterized naturally diabetic non-human primate (NHP) models. Our diabetic NHP models develop diabetic kidney disease with similar phenotypes as human patients, including hyperglycemia, glycosuria, albuminuria, and low GFR, providing the ideal animal model for investigating the mechanisms underlying human DKD, as well as for pharmaceutical discovery, development, and evaluation of novel therapeutic agents.


PriMed Spontaneous Diabetic Kidney Disease NHP Capability

 Set up 100 DKD rhesus macaques database


  With longitudinal (> 5 years) medical records, including echo, clinical pathology, body weight, food intake, vet treatment and dosing record.
  Ultrasound-guided renal biopsy and histopathological examination.
  Biomarkers: GFR, A/C, UAER, C.C.R, NGAL, Cystatin C, TIMP1, et al.
  Well established non-invasive blood pressure measurement using a Dinamap Blood Pressure monitor.
  Enalapril and Entresto have been validated with our DKD NHP model as a benchmark study.
  5 compounds have been validated.

 Imaging capability


  Extensive Echo and MRI experiences with monkey kidney testing.
  Equipped with advanced Echo, MRI and CVI software and Echo PAC Software onsite.
  Kidney fibrosis (T1ρ).
  30-year imaging expert as CSO.

 Pathology and GFR measurement Capability


  Ultrasound-guided renal biopsy.
  Senior consultant has 30+ years of experience in pathology (ACVP from 1989).


Measurement of Glomerular Filtration Rate (GFR) in Rhesus Monkeys is well established

             

 Bleeding at 120, 150, 180, 210, and 240 minutes after the iohexol injection.


 Plasma iohexol concentration measured by HPLC.


 One-compartment model is used to calculate GFR and GFR is corrected according to Brochner-Mortensen and normalized with body surface area. ohexol concentration measured by HPLC.



  




PriMed Posters and Publications


ADA 77th Scientific Sessions, San Diego

27-LB: Diabetic Kidney Disease (DKD) in Nonhuman Primates (NHPs) Is Comparable to Humans for Glomerular Filtration Rate (GFR), Histology, and High-Risk Factors


ADA 75th Scientific Sessions, Boston

544-P: Screening of Diabetic Nephropathy in Spontaneous Type 2 Diabetic Rhesus Monkeys


More information about posters and publications                                                    


Contact Us Right Now




Email : bd@scprimed.com

Tel : +86-28-85921823

Fax : +86-28-62491302

Zip code : 610041

Address : Floor 5, Incubator B4,Tianfu Life & Science Park, No. 88 Southern Keyuan Road,High-tech Zone, Chengdu, Sichuan, China, 610041


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