PriMed Non-human Primate Model of Diabetic Kidney Disease
Diabetes is the largest cause of kidney disease in the world. In fact, approximately 10% to 20% of mortality in diabetic patients is resulted from the kidney (renal) failure.
PriMed Shines provides a large collection of well-characterized naturally diabetic non-human primate (NHP) models. Our diabetic NHP models develop diabetic kidney disease with similar phenotypes as human patients, including hyperglycemia, glycosuria, albuminuria, and low GFR, providing the ideal animal model for investigating the mechanisms underlying human DKD, as well as for pharmaceutical discovery, development, and evaluation of novel therapeutic agents.
PriMed Spontaneous Diabetic Kidney Disease NHP Capability
Set up 100 DKD rhesus macaques database
Pathology and GFR measurement Capability
Measurement of Glomerular Filtration Rate (GFR) in Rhesus Monkeys is well established
Bleeding at 120, 150, 180, 210, and 240 minutes after the iohexol injection.
Plasma iohexol concentration measured by HPLC.
One-compartment model is used to calculate GFR and GFR is corrected according to Brochner-Mortensen and normalized with body surface area. ohexol concentration measured by HPLC.
PriMed Posters and Publications
ADA 77th Scientific Sessions, San Diego
27-LB: Diabetic Kidney Disease (DKD) in Nonhuman Primates (NHP’s) Is Comparable to Humans for Glomerular Filtration Rate (GFR), Histology, and High-Risk Factors
ADA 75th Scientific Sessions, Boston
544-P: Screening of Diabetic Nephropathy in Spontaneous Type 2 Diabetic Rhesus Monkeys
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