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Primed antimicrobial activity evaluation capability

 Collection of ~1500 clinical isolates(~200 drug-resistant bacterium).


 Established multiple in vivo/in vitro assays to evaluate novel antimicrobial compounds.


 Completed screening tests for ~500 compounds and preclinical research of ~80 compounds.


  Tedizolid phosphate ,BAL30072, AZD0914, Micafungin, Fidaxomicin, AmBisome, Avycaz, etc.


Functional Assays In Vitro

 High throughput antimicrobial activity screening


      MIC, MIC50, MIC90, MICrange

      MBC, MBC50, MBC90, MBCrange

      KC, SBA

In vitro drug combination studies

      FIC

Analysis of drug resistance

      Sensitivity (S,I,R)

      Drug inducing resistance

  Structural analysis of ribosomal mutations


In Vivo  Infection Models (Rodent)

 Clostridium difficile-associateddiarrhea (CDAD) Hamster Model


 Lung Infection Models


 Thigh Infection Models


 Systemic Infection Models (bacteria/fungi)


 Others (Subdermal Infection Models/Renal Infection Models/Corneal Infection Models/Vaginal Infection Models/Scalded Skin Infection Models)



~1500 Clinical Isolates

Gram-Positive Bacteria (~600 strains)

      Staphylococcus aureus (MRSA, MSSA)

      Staphylococcus epidermis (MRSE,MSSE)

      Streptococcus (PRSP, PSSP)

      Enterococcus faecium (VRE)

      Enterococcus faecalis (VRE)

      Clostridium difficile

Gram-Negative Bacteria (~800 strains)

      Escherichia coli (ESBLs,CRE)

      Klebsiellapneumoniae ( ESBLs,KPC)

      Oraxella catarrhalis

      Haemophilusinfluenzae

      Enterobactercloacae

      Enterobacteraerogenes

      Acinetobacter baumannii (OXA23, integron type I)

      Proteusbacillusvulgaris

      Salmonella typhi

      Pseudomonas aeruginosa (Integrontype I, IMP4)

      Salmonella

Fungi (~100 strains)     

      Candida krusei

      Candida tropicalis

      Candida albicans

      Mlicrococcus scarlatinae

      Aspergillus niger



   Drug-resistance induction in Haemophilus influenzae 


  


                     In vivo efficacy study



More information about posterand publications                                                 


Contact Us Right Now



Email : bd@scprimed.com

Tel : +86-28-85921823

Fax : +86-28-62491302

Zip code : 610041

Address : Floor 5, Incubator B4,Tianfu Life & Science Park, No. 88 Southern Keyuan Road,High-tech Zone, Chengdu, Sichuan, China, 610041


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