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PriMed Spontaneously Non-Human Primate Model of Obesity

Non-human primates develop spontaneous obesity, metabolic syndrome, and T2DM with characteristics that are extraordinarily like those of humans. Obese, dysmetabolic, and diabetic NHPs also develop hepatic pathology with characteristics of NAFLD/NASH.

PriMed Shines rhesus colony has been studied longitudinally for 7 years under consistent dietary, procedures, and environmental conditions. This consistency is key to the characteristics of obesity, metabolic syndrome, and T2DM, and provides a quickstart for the efficacy study of obesity treatments.


PriMed Shines Spontaneously Obese NHP Capability:

 Breeding center: n=~3000 rhesus macaques (macaca mulatta)


 Colony of n=~500 obese rhesus macaques


 Longitudinal body weight data (monthly)


 Dual Energy X-ray absorptiometry (DEXA) and CT for body composition



Advantages of NHPs in preclinical trials:

 Longitudinal long term studies


 Long enough life span for complication development (and reversal/treatment effects)


 Highly controlled and consistentenvironment


 More valid than rodents forprojecting human outcomes


 Combine pharmacokinetics, efficacyand safety


 Discover new targets and mechanismsof action


 Use of multiple outcome measuresfor validation of future clinical plan




            


           



PriMed Posters and Publications


ADA 77th Scientific Sessions, San Diego

1993-P: Adaptation of Slow- and Fast-twitch Skeletal Muscles to Type 2 Diabetes Mellitus (T2DM) in Diabetic Rhesus Monkeys: an Initial Experience with Non-contrast MRI Microcirculation Mapping Techniques.


2017 Keystone Symposium on Bile Acid Receptors as Signal Integrators in Liver and Metabolism, Monterey 

Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Nonhuman Primates (NHP’s) is Comparable to Humans for Metabolic Features, Histology and Imaging


ICO 2016, Vancouver

Quantification Of Hepatic Fat In Naturally-occurring Nonalcoholic Fatty Liver Disease (NAFLD) In Obese Rhesus Monkeys Using Dual-energy CT (DECT)


ADA 75th Scientific Sessions, Boston

2122-P: Effects of a Long-Acting Formulation of Exenatide on Glucose and Weight Control in Type 2 Diabetic Rhesus Monkeys


More information about posterand publications                                                   


Contact Us Right Now





Email : bd@scprimed.com

Tel : +86-28-85921823

Fax : +86-28-62491302

Zip code : 610041

Address : Floor 5, Incubator B4,Tianfu Life & Science Park, No. 88 Southern Keyuan Road,High-tech Zone, Chengdu, Sichuan, China, 610041


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